An efficient industrial process for the preparation of fluvastatin sodium
نویسندگان
چکیده
A convergent synthesis of highly potent HMG-COA reductase inhibitor Fluvastatin. This protocol is amenable to scale up and will be a valuable process for the commercial production of fluvastatin sodium.
منابع مشابه
A practical and convenient method for the synthesis of anesthetic drug thiopental: using thiourea and sodium ethoxide
A general, simple, practical and convenient method has been described for the synthesis of anesthetic drug thiopental using thiourea in the presence of sodium ethoxide. Anesthetic drug of thiopental was prepared in two stages; during the first stage, the alkylation of mthyl cyanoacetate was performed which was then to be followed by cyclization. Alkylation of methyl cyanoacetate which was perfo...
متن کاملNaHSO4-SiO2: An Efficient Reusable Green Catalyst for Selective C-3 Propargylation of Indoles with Tertiary Propargylic Alcohols
Although several methods for the preparation of 4o propargyl indole derivatives have been published, this synthetic transformation is complicated by the tendency of 3o propargyl alcohols to form allenium intermediates in acidic media. It is therefore a challenge to find an efficient method for the C-3 propargylation of indoles with 3° propargylic alcohols. In this pa...
متن کاملFinding efficient frontier of process parameters for plastic injection molding
Product quality for plastic injection molding process is highly related with the settings for its process parameters. Additionally, the product quality is not simply based on a single quality index, but multiple interrelated quality indices. To find the settings for the process parameters such that the multiple quality indices can be simultaneously optimized is becoming a research issue and ...
متن کاملDesign, Optimization Process and Efficient Analysis for Preparation of Copolymer-Coated Superparamagnetic Nanoparticles
Magnetic nanoparticles (MNPs) are very important systems with potential use in drug delivery systems, ferrofluids, and effluent treatment. In many situations, such as in biomedical applications, it is necessary to cover inorganic magnetic particles with an organic material, such as polymers. A superparamagnetic nanocomposite Fe3O4/poly(maleic anhydride-co-acrylic acid) P(MAH-co-AA) with a core/...
متن کاملIn situ ion substitution of sodium gluconate: Comparison of bipolar membrane electrodialysis and electro-membrane reactor for producing gluconic acid
Based on the home-made cation-exchange membrane (CEM) and bipolar membrane (BPM), electrodialysis with bipolar membrane (EDBPM) and electro-membrane reactor with three compartments (EMR-3) were developed to achieve in situ ion substitution and recovery of gluconic acid (GLH) from its sodium salt. Physicochemical and electrochemical properties of CEM and BPM were studied to assess their...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011